Chromatographic separations economic data

Such novel APIs are to be characterized with respect to, e.g. biotransformation, distribution, PK behaviour and other pharmacological properties. Elaboration of these data will require sensitive, selective and robust analytical methods most presumably based on LC-MS techniques. With respect to optimized economic feasibility procedures should be preferred that allow both (a) reduced consumption of organic solvents for sample preparation and chromatographic separation and (b) short run-time analysis. 

Chromatographic separations of the isotopic isomers of molecules are of interest first because they afford a convenient technique for analysis of mixtures, secondly because scale up in the future might afford economically feasible separations of macroscopic amounts of material, and finally because the values of the separation factors and their temperature coefficients are of intrinsic theoretical interest. This last follows because such data are straightforwardly related to the understanding of isotope effects on solution and adsorption processes and of the intermolecular forces which give rise to these effects. We have approached the general problem... 

---