Chromaffin cells serotonin

Schroeter S, Levey Al, Blakely RD (1997) Polarized expression of the antidepressant-sensitive serotonin transporter in epinephrine-synthesizing chromaffin cells of the rat adrenal gland. Mol Cell Neurosci 9 170-184... 

Mastoparan, INLKALAALA KKILa, a 14-peptide amide found in the venom of wasps. Mastoparan degranulates mast cells and induces the release of catecholamines and serotonin from adrenal chromaffin cells or platelets. Mastoparan C, [Leu , Val ]mastoparan, and crabolin... 

Certain cell types, in particular chromaffin and mast cells, are known to synthesize and release more than one messenger molecule. Chromaffin cells synthesize, store, and release epinephrine and norepinephrine, while mast cells synthesize and release serotonin and histamine. In an attempt to determine if corelease of these molecules takes place in chromaffin cells, Pihel et al. used fast scan cyclic voltammetry with a scan rate of 800 V/sec repeated every 16.7 msec at a S-pm diameter carbon fiber UME (6). Expanded potential scan limits were employed to distinguish epinephrine from norepinephrine, because a second oxidation wave is present at large positive potentials for the oxidation of epinephrine o-quinone, an amine, to the imine form of the molecule. The second oxidation wave made it possible to determine whether an individual release event was attributable to epinephrine or norepinephrine. The results from this smdy suggest that the majority of chromaffin cells release either norepinephrine or epinephrine. However, 17% of the cells observed released both epinephrine and norepinephrine, and each secretory vesicle contained either epinephrine or norepinephrine, but in general not both. 

Pet-1 is an ETS-domain transcription factor that was first discovered in adrenal chromaffin-derivd PC 12 cells, where it was found to induce transcription of the nicotinic acetylcholine 34 receptor (175). Pet-1 is expressed in the adrenal medulla as well as the eye and the brain (175) within the brain, it is expressed exclusively in serotonin neurons (176,177). Pet-1 expression appears... 

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