Cholinergic REM induction test

To summarize, there is now some consistent evidence that diminished SWS and/or a REM sleep disinhibition profile are important correlates of depressive vulnerability and, as such, could be considered as trait markers of affective disorders. In this regard, and although the aforementioned studies need to be replicated, one may already suggest that the cholinergic REM induction test could be considered as an evidence of a cholinergic supersensitivity as a trait or vulnerability marker of affective illness. 

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