Agonists cholinergic receptors

Nicotinic Receptor Agonists. There has been significant activity in the development of muscarinic cholinergic receptor agonists for dementia. In addition, agents that interact with nicotinic cholinergic receptors may also have therapeutic value. Nicotinic receptors have been reported to be... 

Mecfianism of Action A cholinergic-receptor agonist that binds to acetylcholine receptors, producing both stimulating and depressant effects on the peripheral and central nervous systems. Therapeutic Effect Provides a source of nicotine during nicotine withdrawal and reduces withdrawal symptoms. 

Shannon, H.E., Rasmussen, K., Bymaster, F.P., Hart, J.C., Peters, S.C., Swedberg, M.D.B., Jeppesen, L., Sheardown, M.J., Sauer-berg, P., and Fink-Jensen, A. (2000) Xanomeline, an M1/M4 preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice. Schizophr Res 42 249-259. 

Synonym Methylpyridylpyrrolidine Chemical/Pharmaceutical/Other Class Ganglionic cholinergic-receptor agonist... 

Cholinergic receptor agonists Muscarinic receptors Benzyl quinolone carboxylic acid analogs Cevimeline EUK1001 Lanomeline Vedaclidine Nicotinic receptors Nicotinic analog ZY-1... 

I. drugs enhancing cholinergic activity a. cholinergic receptor agonists i. acetylcholine-like agonists... 

Cholinergic receptor agonists are used in correcting accommodative esotropia, an ocular disease in young children. 

Cholinergic receptors Receptors for acetylcholine are classified into muscarinic (muscarine is a selective agonist) and nicotinic (nicotine is a selective agonist). There are five muscarinic (mj to m5) and two nicotinic (neuronal, or ganglionic, and skeletal muscular) subtypes. 

The intrinsic complexity and the multiplicity of cholinergic receptors became evident upon elucidation of their primary structures. In the CNS, at least nine different sequences of a subunits and three different sequences of (3 subunits of the nicotinic receptor have been identified [10, 11]. Expression of the cloned genes encoding certain subunit combinations yields functional receptors with different sensitivities toward various toxins and agonists. 

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