Choline nitrite

Choline nitrite, or pseudo-muscarine, was at one time thought to be identical with natural muscarine, the highly poisonous alkaloid of the mushroom Amanita muscaria (Fly Agaric), and to be the aldehyde corresponding to choline. Both suppositions are wrong. The natural alkaloid is much more toxic than choline nitrite, and its effects are antagonised by atropine, which has little protective effect against the synthetic ester. 

LED, lowest effective dose ElID, highest ineffective dose in-vitro tests, p.g/mL in-vivo tests, mg/kg bw/day Negative in the presence of 30 mM choline In the presence of sodium nitrite or nitrate at pH 8.6 and 5 GI50, concentration causing 50% growth inhibition... 

Diethanolamine is metabolized by biosynthetic routes common to endogenous alkanolamines (ethanolamine and choline) and incorporated into phospholipids. It is excreted predominantly unchanged with a half-life of approximately one week in urine. In the absence of sodium nitrite, no conversion to TV-nitrosodiethanolamine is observed. Diethanolamine competitively inhibits the cellular uptake of choline in vitro and hepatic changes in choline homeostasis, consistent with choline deficiency, are observed in vivo. 

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