Choline acetylase acetyltransferase

Evidence that acetylcholine is a chemical mediator of synaptic transmission elsewhere in the central nervous system is circumstantial but convincing. Acetylcholine is the transmitter substance from motor nerves, preganglionic autonomic fibres and the postganglionic fibres of the parasympathetic system to their respective effector cells. In all these fibres, the activity of choline acetyltransferase (choline acetylase), the enzyme responsible for the synthesis of acetylcholine, is high. Conversely, its activity is negligibly low in sensory nerve fibres and transmission from these fibres is demonstrably non-cholinergic in nature . It is reasonable, therefore, to... 

Acetyl-CoA choline 0-acetyltransferase (EC 2.3.1.6) or choline acetylase Acelyl-CoA CoA... 

Choline Acetvlase - Choline acetyltransferase, the enzyme responsible for the synthesis of acetylcholine from choline and acetylcoenzyme A, was first studied in cell-free preparations by Nachmansohn and Machado O. Even though the Importance of choline acetylase Is as great as that of acetylcholinesterase, much less Interest has been centered on the enzyme responsible for the synthesis of acetylcholine than on the enzyme responsible for Its hydrolysis, until fairly recently. The properties of choline acetyltransferase isolated from squid ganglia... 

ACh synthesis is carried out in the neuron by means of the coenzyme A (CoA) and a specific enzyme, choline-acetylase (ChAc, choline-acetyltransferase), which transfers the acetyl radical from active acetate (acetyl CoA) to choline (see literature in ref. 16) ... 

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