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Cholesterol-tethered

Cholesterol-tethered polymers found utility for attachment of modified polymers to the cells. Cholesterol-PEG-P-DLA copolymer (CPEG-PDLA) has been reported for pro-... [Pg.47]

The tBLM approach was successfully used to immobilise cytochrome bo3 (cbo3), a ubiquinol oxidase from Escherichia coli [35]. The tBLM was formed on gold surface functionalised with cholesterol tethers which inserted itself into the... [Pg.229]

Under the same conditions, tricyclo[5.3.1.0]undecanes are accessible from 5-sub-stituted 2-cyclohexen-l-one as 2-370 with a shorter tether by one CH2-group. Recently, another Michael/Michael/aldol transformation was employed by Paulsen and coworkers to obtain access to the central aromatic core of compounds as 2-376 (Scheme 2.89) [206]. It is of value that such products are thought to act as cholesterol ester transfer protein (CETP) inhibitors, and the application of these drugs should prevent reduction of the HDL-cholesterol level and therefore reduce the risk of coronary heart diseases [207]. [Pg.107]

Decreased free cholesterol in the cell provokes cleavage of SREBP from its tether (cholesteryl esters do not influence the activation of SREBF). [Pg.368]

Lipid rafts on cell membranes are cholesterol- and sphingolipid-rich domains that function as platforms for signal transduction and other cellular processes [6], Tethered lipid bilayers have been proposed as a promising model membrane to describe the structure and function of cell membratKs [7]. Based on these facts, we endeavor to array the lipid rafts as a form of tethered bilayer lipid membrare into the nanopattemed substrates to generate a raft membrane-based biosensing platform (Fig. Ic). [Pg.555]

Duncan, D.C. Whitten, D.G. H-1 NMR investigation of the eomposition. stmeture, and dynamics of cholesterol-stilbene tethered dyad organogels. Langmuir 2000, 16, 6445-6452. [Pg.595]

In 2011, Pikuleva s group [1952] reported a stmcture of bovine P450 llAl bound to 22-hy-droxycholesterol, the first reaction product (from cholesterol). The active site cavity can be described as a long curved tube that extends from the surface to the heme group. (A linker was used to tether adrenodoxin to P450 llAl.) The [2Fe-2S] iron clnster of adrenodoxin was positioned 17 A away from the heme iron of P450 llAl. [Pg.633]

Fig. 1 (A) Schematic representation of a tBLM formed on a mixed self-assembled monolayer of tether (cholesterol) and spacer molecules (6-mercaptohexanol). (B) Cole-Cole plots for cbo3 before and after formation of a tBLM measured at 0 V vs. SCE. Adapted with permission from [35]. Copyright (2006) American Chemical Society... Fig. 1 (A) Schematic representation of a tBLM formed on a mixed self-assembled monolayer of tether (cholesterol) and spacer molecules (6-mercaptohexanol). (B) Cole-Cole plots for cbo3 before and after formation of a tBLM measured at 0 V vs. SCE. Adapted with permission from [35]. Copyright (2006) American Chemical Society...

See other pages where Cholesterol-tethered is mentioned: [Pg.460]    [Pg.460]    [Pg.228]    [Pg.519]    [Pg.46]    [Pg.261]    [Pg.2225]    [Pg.368]    [Pg.368]    [Pg.260]    [Pg.432]    [Pg.433]    [Pg.640]    [Pg.640]    [Pg.32]    [Pg.167]    [Pg.35]    [Pg.273]    [Pg.323]    [Pg.236]    [Pg.58]    [Pg.61]    [Pg.63]    [Pg.715]    [Pg.148]   


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Tether

Tethering

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