Cholangiodestructive cholestasis

Cholestasis may be transient or chronic (Treinen-Moslen, 2001) and may be subdivided into canalicular cholestasis and cholangiodestructive cholestasis. Canalicular cholestasis can be produced by drugs or other chemicals that damage the bile canalicular structure... 

Cholangiodestructive cholestasis is caused by bile duct obstruction, which may be intrahepatic or extrahepatic. Bile duct injury may lead to the sloughing of epithelial cells into the lumen, cell edema, and inflammation, which may contribute to obstruction (Treinen-Moslen, 2001 Plumlee, 2004). Chronic lesions associated with cholangiodestructive cholestasis typically include bile duct proliferation and periductular fibrosis. Vanishing bile duct syndrome, characterized by a loss of bile ducts, has been seen in chronic cholestatic disease in humans (Zimmerman, 1999 Treinen-Moslen, 2001) and has been produced experimentally in dogs (Uchida et al., 1989). 

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