Chohne acetyltransferase

Hiramatsu M, Edamatsu R, Mori A. Free radicals, hpid peroxidation, SOD activity, neurotransmitters and chohne acetyltransferase activity in the aged rat brain. EXS 1992 62 213-218. 

Hiramatsu M, Haba K, Edamatsu R, Hamada H, Mori A. Increased chohne acetyltransferase activity by Chinese herbal medicine Sho-saiko-to-go-keishi-kashakuyaku-to in aged rat brain. Neurochem Res 1989 14 249-251. 

Neurochemical examination of biopsy and antopsy brain material from Alzheimer patients has revealed loss of the presynaptic marker enzymes acetyl coenzyme A (acetyl-CoA), chohne 6>-acetyltransferase and acetylcholinesterase (AChE), and of muscarinic receptor sites of the M2 subtype correlating with dementia score and severity of nenrohistopathology [8]. These alterations do, to some extent, reflect the well-documented neuronal cell loss in the nucleus of Meynert in presenile dementia and AD. Lesions of this brain nncleus in rats, a limited model for the cholinergic deficit of AD, resnlt in marked reductions in the levels of cholinergic en me markers in the neocortex accompanied by great decreases in the total muscarinic receptor levels [9,10]. 

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