Phenmetrazine Chlorpromazine

Noninterfering acetaminophen, aspirin, amitriptyline, huprenorphine, caffeine, carba-mazepine, chlorpromazine, desipramine, dextromethorphan, doxepin, ephedrine, fenfluramine, imipramine, lidocaine, loxapine, meperidine, methadone, methaqualone, naloxone, naltrexone, nicotine, orphenadrine, oxycodone, papaverine, pentazocine, phendimetra-zine, phenmetrazine, phentermine, phenylpropanolamine, phenytoin, primidone, procaine, promethazine, propoxyphene, propyphenazone, theobromine, theophylline, trazodone, triflupromazine, trimethoprim, trimipramine... 

Noninterfering amitriptyline, amphetamine, atropine, benzoylecgonine, benztropine, caffeine, carbamazepine, carisoprodol, chlorpheniramine, chlorpromazine, chlorprothixene, cimetidine, cocaine, codeine, dextromethorphan, diazepam, diphenhydramine, diphenox-ilate, disopyramide, doxepin, dojylamine, emetine, erythromycin, flurazepam, gluteth-imide, hydrocortisone, hydromorphone, hydroxyzine, imipramine, lidocaine, loxapine, meperidine, meprobamate, methadone, methamphetamine, methapyrilene, methaqualone, methocarbamol, methylphenidate, nicotine, nordiazepam, nortriptyline, orphenadrine, papaverine, pentazocine, phenacetin, phencyclidine, phenmetrazine, phenolphthalein, phentermine, phenylpropanolamine, phenytoin, prazepam, procaineimide, procaine, propoxyphene, propranolol, protriptyline, pseudoephediine, pyrilamine, quinine, salicylam-ide, spironolactone, strychnine, terpin hydrate, thioridazine, thiothixene, triamterene, trifluoperazine, triflupromeizine, trihexyphenidyl, trimeprazine, trimethobenzamide, trimethoprim, tripeleimamine... 

Noninterfering amitriptyline, amobarbital, ampicillin, butabarbital, butalbital, celbenine, chlordiazepoxide, chlorpromazine, clorazepate, desipramine, diazepam, doxepin, ethchlor-vynol, fluphenazine, hydroxyzine, ibuprofen, imipramine, isoniazid, lidocaine, mephobarbital, mesoridazine, methaqualone, methyluric acid, naprotyline, nordiazepam, nortriptyline, oxazepam, pentobarbital, perphenazine, phenelzine, phenmetrazine, phenobarbital, phenylbutazone, phenjdoin, prednisolone, prednisone, procainamide, prochlorperazine, promazine, promethazine, propoxyphene, protriptyline, pyrilamine, secobarbital, thioridazine, thiothixene, timolol, trazodone, triazolam, trifluoperazine... 

The appetite suppressant and other effects of amfetamines, chlo-rphentermine and phenmetrazine are opposed by chlorpro-mazine. It seems possible that other phenothiazine will interact similarly. The antipsychotic effects of chlorpromazine can be opposed by dexamfetamine. 

Established interactions. These reports suggest that it is not beneficial to attempt to treat patients taking chlorpromazine with amfetamines, such as dexamfetamine, or other central stimulants such as phenmetrazine. In one study, thioridazine also appeared to interact. However, it is not clear whether this interaction takes place with antipsychotics other than chlorpromazine, but it seems possible with the phenothiazines, especially if the suggested mechanism is correct. Note that central stimulants are no longer recommended for the treatment of obesity. 

Reid AA. Pharmacological antagonism between chlorpromazine and phenmetrazine in mental hospital patients. Med JAust (1964) 10,187-8. 

Sletten IW, Ognjanov V, Menendez S, Sundland D, El-Toumi A. Weight reduction with chlo-rphentermine and phenmetrazine in obese psychiatric patients during chlorpromazine therapy. Curr TherRes (1967) 9, 570-5,... 

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