Lithium compounds Chlorpromazine

The activity of a benzothiadiazine (XXXI) was gported as comparable to chlorpromazine in animal experiments. Initial clinical trials indicated promise that the imidazoline XXXII might be a worthwhile antidepressant, A review on the therapeutic use of lithium carbonate in the treatment of mania, excitement, epilepsy and premenstral tension has been given by Noyes. This compound has just been approved for introduction on the U.S, market (April, 1970). 

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