Chlorpromazine hormonal

The results of metyrapone tests for Cushing s syndrome will be unreliable in patients taking cyproheptadine and phenjdoin, and therefore these should be withdrawn prior to the test. The manufacturer also states that barbiturates, antidepressants (they name amitriptyline) and antipsychotics (they name chlorpromazine), hormones that affect the hypothala-mo-pituitary axis, and antithyroid drugs may influenee the results of the test. They recommend that, if any of these drugs cannot be withdrawn prior to the test, the necessity of earrying out the metyrapone test should be reviewed. ... 

Chlorpromazine increases the release of endogenous antidiuretic hormone and can therefore potentiate the antidiuretic effect of desmopressin (77). 

It has since been assumed that this is the therapeutic action of tricyclic antidepressants, which are sometimes referred to as monoamine reuptake inhibitors or MARIs. However the exact significance of this reuptake process is unknown, especially as the tricyclic antidepressants have numerous other actions and influence, directly or indirectly, almost all neurotransmitters, many neuropeptides and most hormones (Khan 1999). Further studies of reuptake by heart muscle preparations showed that chlorpromazine was a stronger reuptake inhibitor than imipramine and not all the tricyclic antidepressants had this action (Lahti Maickel 1971). In addition, it has not been possible to demonstrate that reuptake inhibition is actually correlated with increased availability or activity of noradrenalin or serotonin. In fact most evidence suggests that tricyclic drugs reduce levels of noradrenalin (Frazer Mendels 1977 Heydorn, Frazer, Mendels 1980 Schildkraut, Winokur, Applegate 1970). 

The promotion of mammary development, lactation, and galactopoiesis requires growth hormone, ovarian estrogen (duct formation), ovarian progesterone (lobule-alveolar development), and adrenal corticoids, as well as prolactin and oxytocin. The secretion of prolactin is modified by snbstances that stimulate or block dopamine-receptor sites. Agents such as neuroleptics (chlorpromazine) may cause lactation in a nonpregnant woman. On the other hand,... 

Chlorpromazine may have weak diuretic effects because of a depressant action on the secretion of vasopressin (antidiuretic hormone, ADH), inhibition of reabsorption of water and electrolytes by a direct action on the renal tubule, or both. The syndrome of idiopathic polydipsia and hyponatremia sometimes associated with psychotic illness has respotuled to clozapine, presumably via... 

K3. Kato, Y., Chichasa, K., Ohgo, S., and Imura, H., Inhibiting effect of somatostatin on growth hormone release induced by isoprenaline or chlorpromazine in rats. /. Endocrinol. 62, 687-688 (1974). 

The differences between the groups is held to suggest that chlorpromazine increases melanin production only in certain circumstances in this study, in the presence of a high level of melanin production and when oestrogenic hormones were at high levels. The effect of chlorpromazine in increasing sensitivity to light is not, on its own, sufficient to induce melanosis (70 ). 

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