Dexamfetamine Chlorpromazine

INDIRECT ANTIPSYCHOTICS 1. Case reports of paralytic ileus with trifluoperazine and methylphenidate 2. Case report of acute dystonias with haloperidol and dexamfetamine 3.1 efficacy of chlorpromazine when dexamfetamine was added 1. Additive anticholinergic effect 2. Uncertain possibly due to t dopamine release 3. Uncertain 1. Watch for signs of altered bowel habit 2. Warn patients of this rare interaction 3. Avoid co-administration... 

The appetite suppressant and other effects of amfetamines, chlo-rphentermine and phenmetrazine are opposed by chlorpro-mazine. It seems possible that other phenothiazine will interact similarly. The antipsychotic effects of chlorpromazine can be opposed by dexamfetamine. 

A study in 462 patients taking chlorpromazine 2(X) to 6(X) mg daily indicated that the addition of dexamfetamine 10 to 60 mg daily had a detrimental effect on the control of their schizophrenic symptoms. ... 

Established interactions. These reports suggest that it is not beneficial to attempt to treat patients taking chlorpromazine with amfetamines, such as dexamfetamine, or other central stimulants such as phenmetrazine. In one study, thioridazine also appeared to interact. However, it is not clear whether this interaction takes place with antipsychotics other than chlorpromazine, but it seems possible with the phenothiazines, especially if the suggested mechanism is correct. Note that central stimulants are no longer recommended for the treatment of obesity. 

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