Chlorpromazine Coumarins

Phenobarbital and Barbiturates, chloramphenicol, chlorpromazine, cortisol, coumarin anticoagulants,... 

Phenobarbital and other barbiturates1 Barbiturates, chloramphenicol, chlorpromazine, cortisol, coumarin anticoagulants, desmethylimipramine, digitoxin, doxorubicin, estradiol, phenylbutazone, phenytoin, quinine, testosterone... 

Also analyzed acepromazine, acetaminophen, acetophenazine, albuterol, aminophylline, amitriptyline, amobarbital, amoxapine, eunphettunine, amylocaine, antipyrine, aprobar-bital, aspirin, atenolol, atropine, avermectin, barbital, benzocaine, benzoic acid, benzotro-pine, benzphetamine, berberine, bibucaine, bromazepan, brompheniramine, buprenor-phine, buspirone, butabarbital, butacaine, butethal, caffeine, carbamazepine, carbromal, chloramphenicol, chlordiazepoxide, chloroquine, chlorothiazide, chloroxylenol, chlorphe-nesin, chlorpheniramine, chlorpromazine, chlorpropamide, chlortetracycline, cimetidine, cinchonidine, cinchonine, clenbuterol, clonazepam, clonixin, clorazepate, cocaine, codeine, colchicine, cortisone, coumarin, cyclazocine, cyclobenzaprine, cyclothiazide, cyheptamide, cymarin, danazol, danthron, dapsone, debrisoquine, desipramine, dexamethasone, dex-... 

Although in one early report, chlorpromazine 40 to 100 mg daily was said to have slightly sensitised 2 out of 8 patients to the effects of acenocoumarol and in another was reported to increase its anticoagulant effects in animals, there appears to be nothing else published to suggest that an interaction occurs. In vitro study in human liver microsomes found that chlorpromazine did not inhibit CYP2C9, the cytochrome P450 isoenzyme predominantly involved in the metabolism of warfarin , (p.358) and other coumarins. No eoumarin dose adjustments would therefore be anticipated to be needed on eoneurrent use. 

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