Chlorpheniramine maleate -loaded

R. Bodmeier, O. Paeratakul, Process and formulation variables affecting the drug release from chlorpheniramine maleate-loaded beads coated with commercial and self-prepared aqueous ethylcellulose pseudolatexes, Int J Pharm, 70 59-68,1991. 

An increase in drug load resulted in an increased release rate. Release profiles for spheres containing actives having different solubilities, including chlorpheniramine maleate, quinidine sulfate, theophylline, and hydrochlorothiazide are shown in Figure 20. An increase in drug solubility resulted in an increased release rate (53). 

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