Chlorotrimethylsilane related reagents

Related Reagents. r-Butyldimethylchlorosilane Chlorotri-ethylsilane Chlorotrimethylsilane. 

Related Reagents. )V,0-Bis(trimethylsilyl)acetamide N,N -Bis(trimethylsilyl)urea Chlorotrimethylsilane Hexamethyldisi-lazane )V-(Trimethylsilyl)imidazole. 

Related Reagents. r-Butyldimethylchlorosilane r-Butyl-dimethylsilyl Trifluoromethanesulfonate Chlorotrimethylsilane Chlorotriphenylsilane Triethylsilyl Trifluoromethanesulfonate Trimethylsilyl Trifluoromethanesulfonate. 

Related Reagents. f-Butyldimethylsilyl Trifluoromethane-sulfonate Chlorotrimethylsilane lodotrimethylsilane Triethyl-silyl Trifluoromethanesulfonate. 

The trimethylsilyl group was the first to be developed and is widely used for the protection of serine and threonine (Table 6). Chlorotrimethylsilane, l,14 3,3,3-hexamethyldisilazane, and A(0-bis(trimethylsilyl)acetamide are commercially available reagents used for the conversion of alcohols into the corresponding trimethylsilyl derivatives.Furthermore, trimethylsilyl cyanide has been used to protect the side chains of serine, threonine, and ty-rosine.f This silyl protection allows the formation of A -carboxyanhydrides from H-Ser(TMS)-OH and H-Thr(TMS)-OH, and their application in peptide synthesis in the aqueous phase.f l The TMS group can be removed under various conditions, depending on the kind of functional group to which it is bound the TMS ethers are more stable than related amino or carboxy derivatives.These differences in stability allow the direct application of completely silylated hydroxy amino acids in peptide synthesis.b ... 

Hexamethyidisilthiane, [(CHalaSiJaS. Mol. wt, 178.44, b.p. 163°. The disilthiane is prepared by reaction of chlorotrimethylsilane with sodium sulfide (96% yield). Reduction of sulfoxides. This reagent and the related hexamethylcyclo-trisilthiane reduce sulfoxides to sulfides at 25-60° in 70-90% yield. ... 

---