Warfarin Chlorothiazide

The principal precaution with use of the bile acid resins is the possibility of impaired absorption of other drugs given orally at the same time. Cholestyramine and colestipol can bind many other drugs, such as digitoxin, phenobarbital, chlorothiazide, and warfarin, and delay or prevent their absorption. For this reason, other drugs should always be taken at least 1 hour before or 4 to 6 hours after the resin. The resins can also decease absorption of fat-soluble vitamins. 

Choiestyramine Warfarin, phenylbutazone, digitoxin, cephalexin and chlorothiazide Decreased absorption... 

Albumin X 4 X X HIV protease inhibitors, atenolol, cimetidine, chlorothiazide, chlorpromazine, losartan, phenytoin, tamoxifen, warfarin Aungst et al., 2000... 

Also analyzed acetazolamide, chlorothiazide, chlorthalidone, furosemide Noninterfering acetaminophen, bumetanide, caffeine, phenylbutazone, salicylic acid, sul-famerazine, sulfamethiazole, sulfamethoxazole, sulfamonomethoxine, sulfisomidine, sul-fisoxazole, theophylline, tolbutamide, warfarin... 

Noninterfering acetaminophen, acetylmorphine, amiodarone, amobarbital, amphetamine, bendroflumethiazide, benzocaine, benzoylecgonine, benzthiazide, butalbital, carbamaze-pine, chlorothiazide, clonazepam, cocaine, codeine, cotinine, cyclosporine, cyclothiazide, desalkylflurazepam, diamorphine, dicumerol, ephedrine, ethaciynic acid, ethanol, eth-chlorvynol, ethosuximide, furosemide, glutethimide, hydrochlorothiazide, hydrocodone, hydroflumethiazide, hydromorphone, lorazepam, mephentermine, meprobamate, meth-amphetamine, metharbital, methoxsalen, methoxyphenteramine, methsuximide, meth-ylcyclothiazide, metoprolol, MHPG, monoacetylmorphine, morphine, normethsuximide, oxazepam, oxycodone, oxymorphone, pentobarbital, phencyclidine, phenteramine, phenylephrine, phenytoin, polythiazide, primidone, prochlorperazine, salicylic acid, sulfanilamide, THC-COOH, theophylline, thiazolam, thiopental, thioridazine, tocainide, trichlo-romethiazide, trifluoperazine, valproic acid, warfarin... 

The loop diuretics, bumetanide, furosemide and torasemide, the potassium-sparing diuretic spironolactone, and the thiazides chlortalidone and chlorothiazide, have all been shown either not to interact or to cause only a small reduction in the effects of the coumarin anticoagulants of minimal or no clinical importance. The lack of reports of clinically relevant interactions su ests that, in general, diuretics do not interact with anticoagulants. The possible exception is etacrynic acid, which on rare occasions has caused a marked increase in the effects of warfarin. 

A study in 8 healthy subjeets given single 40 to 60-mg doses of warfarin before and after chlorothiazide 1 g daily for 21 days found that the mean half-life of the anticoagulant was increased from 39 to 44 hours, but the prothrombin time was only deereased by 0.3 seeonds. ... 

---