Chlorotetrolic esters

Chlorosulfonyl isocyanate Sulfuryl chloride isocyanate, (1189-71-5), 65, 135 Chlorotetrolic esters, 65, 47... 

Chlorotetrolic esters are small, highly functionalized, reactive molecules of particular interest is the possibility of using them as reagents for chemical modification of biological macromolecules. Different protein nucleophiles react under mild conditions with methyl 4-chloro-2-butynoate by addition across the triple bond and/or substitution of chlorine while the triple bond and the ester group are involved in the reaction of chlorotetrolic... 

The present synthesis illustrates a convenient preparation of chlorotetrolic esters which can be performed in one step starting from commercially available and inexpensive products it 1s faster and gives better yields as compared with the overall yields of the multistep preparations described earlier. Since chlorotetrolic acid is not an intermediate 1n this synthesis, the necessity of distilling this explosive product is eliminated. In contrast to the acid, explosions were never observed during distillations of the lower boiling chlorotetrolic esters. 

Chlorotetrolic esters are small, highly functionalized, reactive molecules of particular interest is the possibility of using them as reagents for chemical modification of biological macromolecules. Different protein... 

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