7-chlorokynurenic acid

Chlorokynurenic acid 5,7-Dichlorokynurenic acid Scheme 3 Structures of kynurenic acid derivatives. 

Other attempts make use of the better CNS penetration of kynurenine which is converted enzymatically within the brain to kynurenic acid by kynurenine aminotransferase (Hokari et al., 1996) or the design of pro-drugs which enter the CNS more easily and are hydrolyzed within the brain e g. glucosidic-linked 7-chlorokynurenic acid (Bonina et al., 2000). 

Scheme 4 Enzyme-catalyzed formation of 7-chlorokynurenic acid.

Hokari, M., Wu, H. Q., Schwarz, R., Smith, Q. R. Facilitated brain uptake of 4-chlorokynurenine and conversion to 7-chlorokynurenic acid, Neuroreport 1996, 8, 15-18. 

Kemp, J. A., Foster, A. C., Leeson, P. D., Priestley, T., Tridgett, R., Iversen, L L., Woodruff, G. N. 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex, Proc. Natl. Acad. Sci. USA 1988, 85, 6547-6550. 

On the other hand, it was demonstrated that 7-chlorokynurenic acid and 5,7-dichloroky nurenic acid were efficiently taken up by the LAT in the brain when they were administered as their amino acid precursors L-4-chlorokynurenine andL-4,6-dichlorokynurenine (121). In the brain, these precursors were converted again to the parent compounds. 

Chlorogenic acid 14.2p, 14.5p Chlorogenin-Glc 10.2t Chlorogenin-Glc-Glc 10.2t Chlorogenin-Glc-Glc-Glc 10.2t Chlorokynurenic acid 3.3An C hlorophenyl-di methoxy-quinazolinami ne 8.3Cn... 

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