1 -Chlorobenzotriazole oxidation with

The perimidines should be A-substituted to avoid oxidation. With A-chlorobenzotriazole, chlorination leads to a mixture of 4- and 9-chloro derivatives. With 2 equivalents the 4,9-dichloro derivative results. Subsequent chlorinations yield the 4,7,9-trichloro and the tetrachloro derivative. 

Oxidations with 1-chlorobenzotriazole Ketones from sec. alcohols... 

Dithioketal, removal of 536 Dithiolanes, alkylation of 527 conversion to thiols 243 optical dissymmetry effects 366-368 oxidation, with 1-chlorobenzotriazole 525... 

Aldoximes can be oxidatively dehydrogenated to nitrile oxides using a variety of oxidants such as lead tetraacetate [16a], alkali hypohalites [lla],NBS in DMF followed by base treatment [16b], chloramine-T [11b], 1-chlorobenzotriazole [16c], mercuric acetate [ 16 d], etc. However, we employed either NaOCl or chloramine-T for most of our INOC reactions. For instance, a piperidine ring fused to an isoxazoline as in 14 was constructed using the INOC methodology (Scheme 3) [17]. Monoalkylation of N-tosylallylamine 10 with the bromoacetal... 

A simple but accurate potentiometric method for the estimation of mercaptans in 0.01 M perchloric acid is based on their quantitative oxidation to disulfide with 1-chlorobenzotriazole. A backtitration procedure can also be used <90Mi40l-03>. 

Secondary alkyl ethers can be oxidized to ketones by bromine (e,g., Me2CHOCHMe2 + Br — Me2CO).109 Primary alkyl ethers give carboxylic acids (9-22) with bromine, but can be cleaved to aldehydes with l-chlorobenzotriazole.lln... 

Benzotriazole can be chlorinated at the N(l) position by NaOCl (85H(23)2225). 1-Chlorobenzotriazole - a rather stable crystalline compound that has found application in organic synthesis as a selective chlorinating reagent and mild oxidant. A-Fluorination of benzotriazole with cesium fluoroxysulfate gives 1-fluorobenzotriazole in 25% yield (91T7447). 

Oxidation of phenothiazines with 1-chlorobenzotriazole followed a first-order dependence on the oxidant and a zero-order dependence on the reductant concentration. Hypochlorous acid has been suggested as the rective oxidizing species. A mechanism consistent with the observed results has been proposed.155... 

Several medio are available for the intnxluction of sulfenyl groups a to carbonyl derivatives and these have been reviewed. - The most versatile procedure involves reaction of the enolate with an appropriate thiol derivative, but the preferred m od is largely dependent on the nature of the substrate employed (see below). In most instances, sulfur has been introduced in the divalent state and subsequently oxidized, although the oxidative step has been avoided by the direct introduction of sulfur at the S oxidation level. The oxidation of sulfides to sulfoxides is a trivial procedure that can be effected by a variety of reagents. Sodium metaperiodate, m-chloroperbenzoic acid and hydrogen peroxide are the most common oxidants, but r-butyl hydroperoxide, r-butyl hypochlorite, N-chlorobenzotriazole,... 

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