Chlorobenzene as a solvent

Rozenbaum ND, Blekh RS, Kremneva SN, et al. 1947. [Use of chlorobenzene as a solvent from the standpoint of industrial hygiene.] Gig Sanit 12 21-24. (Russian)... 

Notably, use of chlorobenzene as a solvent instead of xylenes allowed us to synthesize tetraindane 112 in moderate yield [49] (Scheme 22). This hydrocarbon contains two Cs- and one C2-diindane units fused in a two-fold angular way (as well as two l,2 -spirobiindanes 12) and it appears to be more strained than expected. According to our schematics for centropolyindanes, 112 has to be classified as a (two-fold) irregular centrotriindane. In this view, both 111 and 112 represent the first derivatives of the irregular triindane 17. 

The almost quantitative monoalkylation of p-aminophenol is claimed by Zimmerli by first forming an aldehyde amine before treating with the methylating agent. With the use of furfural and dimethyl sulfate, the reaction in dry chlorobenzene as a solvent can be represented by the following equations ... 

The most well-known method for the preparation of bis-(4-chlorophenyl)-sulfone is the Friedel-Crafts reaction of 4-chlorobenzenesulfonyl chloride with chlorobenzene, the catalyst used, for example, iron(III) chloride. The reaction is carried out in chlorobenzene as a solvent at about 140 °C. 

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