3-Chloroacetophenone from aluminum

Cadmium chloride as catalyst in conversion of dipotassium 1,8-naph-thalenedicarboxylate to 2,6-naph-thalenedicarboxylic acid, 72 Chlorination, nuclear, aluminum chloride as catalyst for, 9 of pyruvic acid by sulfuryl chloride, 54 Chlorine in oxidation of methyl disulfide to methanesulfinyl chloride, 62 3-Chloroacetophenone from aluminum chloride catalyzed chlorination of acetophenone, 10... 

Nuclear halogenation of acetophenone depends on formation of the aluminum chloride complex. If less than one equivalent of aluminum chloride is used, side-chain halogenation occurs. 3-Bromoacetophenone has been prepared from 3-aminoaceto-phenone by the Sandmeyer reaction. The synthesis described here has been taken from work of the submitters, who have used it to prepare many 3-bromo- and 3-chloroacetophenones and benzaldehydes, as well as more highly halogenated ones (Notes 7 and 8). 

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