4-Chloro-3-sulfamyl benzene sulfochloride

Chloro-3-sulfamyl benzene sulfochloride Manufacturing Process... 

By hydrogenation of a-methyl-a-cyanotetrahydrofuran with Raney nickel as catalyst, a-methyl-a-tetrahydrofurfuryl amine is obtained (BP 48°C/12 mm Hg) which is alkylated by dimethyl sulfate to give a-methyl-a-tetrahydrofurfurylmethylamine (BP 70°C/40 mm Hg). The amine is then reacted with 4-chloro-3-sulfamyl benzene sulfochloride in the presence of an acid acceptor. The mixture is stirred overnight, the solvent (acetone or pyridine) is driven off under vacuum and the residue is recrystallized from alcohol. 

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