1-Chloro-4-nitro-benzene systems

D-Labelling studies establish that a cyclopropylcarbinyl metal complex is an intermediate in the nickel-promoted rearrangement of penta-1,4-diene to isoprene. Studies of homoconjugation in diary Imethyl systems show that there is an important contribution from (844) in the methanolysis of p-(4-chloro-3-nitrobenzyl)nitro-benzene. ... 

The method is easy to handle, readily adaptable to online SPE-HPLC systems, and gives good results for naphthalene sulfonates and benzene sulfonates with nitro, chloro, and alkyl groups. However, apart from the fact that a number of hydrophilic benzene sulfonates (e.g.,... 

Ort/io-selectivity is generally observed in the reactions of 2,4-dichloro- and 2,4-difluoro-nitrobenzene with alkoxide and thiophenoxide ions [199]. Also in less activated systems, nucleophiles generated from phenols and thiophenols with potassium fluoride-alumina and 18-crown-6-polyether will react in DMSO with cyano- or nitro-substituted fluoro- or chloro-benzenes [200]. Interestingly, the reaction of difluorobenzenes with two diffoent alcohols can occur sequentially. Introduction of the first etho" function deactivates the ring, and use of more forcing conditions allows substitution of the second fluorine [201]. Consecutive displacements of fluorine and nitro groups have been observed in the reaction of ort/io-fluoronitrobenzene with chiral acyl bicyclic lactones in a highly enantioselective synthesis of spirooxindoles [202]. 

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