2- Chloro-4,6-diphenyl-pyrimidine

Pyrimidine-2,4( 1H,3 H)-dione, 5-butyl-6-chloro-1,3-diphenyl-synthesis, 3, 113... 

The yields of the pyrimidines 147 and the pyridines 151 are not high and vary greatly, depending on the structure of the starting materials. The latter can also determine the nature of the product. Thus, a mixture of 2,4-dimethyl-6-phenylpyrimidine, 2,4-dimethyl-4,6-diphenyl-4//-l,3-oxazine and 1-chloro-l-phenylethene was obtained by refluxing a 1 3 3 ratio of the acetophenone-benzonitrile-phosphorus oxychloride mixture, followed by treatment of the crude product with sodium carbonate solution .It has been shown that addition of an additional ketone molecule to the iminium intermediate is an alternative to the formation of the A -acylenamines and this route is catalyzed by aluminum chloride. Auricchio and coworkers believe also that the reaction of ketones with nitriles catalyzed with both protic and Lewis acids must be considered as a Ritter reaction (see, however, Section V.C). The cationic intermediate 152 thus formed can undergo either a proton shift giving enamide 153 or addition of another ketone molecule... 

---