Chloral hydrate dosage

Soft gelatin capsules are not an inexpensive dosage form, particularly when compared to direct compression tablets [3]. There is a more intimate contact between the shell and its liquid contents than exists with dry-filled hard gelatin capsules, which increases the possibility of interactions. For instance, chloral hydrate formulated with an oily vehicle exerts a proteolytic effect on the gelatin shell however, the effect is greatly reduced when the oily vehicle is replaced with polyethylene glycol [3]. 

Ingestion of oral dosage forms is the most common route of both accidental and intentional exposures to chloral hydrate. It is available as capsules, tablets, an oral solution, and rectal suppositories. 

Breimer DD, Cox HLM, van Rossum JM (1973) Relative bioavailability of chloral hydrate after rectal administration of different dosage forms. Pharm Weekbl 108 1101-1110... 

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