2-Chlor-2-mcthyl

Hydroxy-phenyl-methan- -bis-[2-chlor-l-chlor-mcthyl-cthylester] XII/1, 478 Hydroxy-phenvl-methan- -bis-[2-chlor-ethylester] XII/1, 478 ... 

Oxo-2-methyl- 273, 605 2-Oxo-3-methyl-l-(4-brom-phenyl)- 675 2-Oxo-3-methyl-1 -(3-chlor-phenyl)- 675 2-Oxo-3-methyl-l-(4-mcthyl-phenyl)- 675 l-Oxo-2-methyl-l -phenyl- 635... 

Phenyl-(4-chlor-phenyl)- 542 Phenyl-(4-fluor-phenyI)- 410 PhenyI-[4-(3-hydroxy-butyl)-phenyl]- 296 Phenyl-(2-hydroxymethyI-phcnyl)- 229 Phenyl-(4-hydroxymethyI-phenyl)- 324 PhenyI-(2-hydroxy-phenyl)- 159 Phenyl-(3-methoxy-phenyl)- 410 Phenyl-(4-mcthyl-phenyI)- 410 Phenyl-naphthyl-(l)- 411 Phenyl-[4-(3-oxo-butyl)-phenyl]- 296 Phenyl-pyridyI-(2)- 492 Phenyl-(2,4,6-trimethyI-phenyl)- 411 Triaryl- 561 Trideutero-... 

Reaction of 2 equiv of 2-aminopyridines with 2-hydropolyfluoroalk-2-anoates 351 in MeCN in the presence of NEt3 at 90 °C for 50 h afforded a mixture of the isomeric 2-oxo-2H- and 4-oxo-4f/-pyrido[l,2-a]pyrimidines 110 and 111. Reaction of 3 equiv of 2-amino-pyridines and 2-hydropoly-fluoroalk-2-enoates 351 in MeCN in the presence K2C03 could be accelerated by ultrasonic irradiation (125 W). 2-Amino-6-methylpyridine yielded only 2-substituted 6-mcthyl-4//-pyrido[l,2-a]pyrimidin-4-oncs 111 (R = 6-Me), whereas 2-amino-5-bromopyridine gave a mixture of 7-bromo-4//-p y ri d o [ 1,2 - a ] p y ri m i d i n -4- o n c (111, R = 7-Br, Rf = CF2C1) and 2-(chlor-o,difluoromethyl)-6-bromoimidazo[l, 2-<2]pyrimidine-3-carboxylate in 44 and 8% yields, respectively (97JCS(P1)981). Reactions in the presence of K2C03 in MeCN at 90°C for 60h afforded only imidazo[l,2-a]pyrimidine-3-carboxylates. 

Auch die Reaktionen von Thiophosphonsaure-chlorid-S-estern mit Natriumalkanolaten oder -phenolaten in Alkoholen bei 20—60°fiihren z.B. in guten Ausbeuten zu 1-Chlor-l-mcthyl-ethan-thiophosphonsaure-0,S-diestern (70-80%)521 S22 ... 

Chlor-a-hydroxy-benzyl)-phenyl- E2, 132 (2-Chlor-1-hydroxy-l-mcthyl-propyl)-ethyl- -propylester E2, 187 -chlorid... 

Anilino-benzyl)-ethyl- -isopropylester-(2-phenyl-hydrazonid) E2, 294 Benzyl-ethyl- -diethylamid E2, 275 Bis-[2-chlor-ethylJ- -chlorid E2, 251 Bis [chlormethyl]- E2, 144 Bis-[chlormethyl]- -chlorid El, 250 Bis-jchlor-phenyl]- -chlorid E2, 249 Bis-[4-chlor-phenyl]- -chlorid E2, 256 Bis-[2-cyan-ethyl]- -S-(4-mcthyl-phenylester)... 

Chlor-l-fluor-2,5-dihydro- -1-oxid E2, 153 l-Chlor-2-methyl-2,5-dihydro- -1-oxid E2, 153 l-Chlor-3-mcthyl-2,5-dihydro- -1-oxid E2, 152,... 

Chlor-3-methyl-l-phenyl-4-phospho- Xll/l, 371 S-(Diethoxy-thiophosphoryloxy)-3-mcthyl-XII/2, 643... 

Chlor-3-mcthyl-2,3-dihydro- E2, 683 2-Chlor-3-methyl-2,3-dihydro- -2-sulfid E2, 683 2-Dialkylamino-3-methyl-2,3-dihydro- E2, 774 2-Dialkylamino-3-mcthyl-2,3-dihydro- -2-sul-fid E2, 774... 

Chloro-3-mcthyl-l-oxo- 2631 3-Chlor-5-methyl-1-0X0- 2631 3-Chlorraethyl-l-oxo- 2071 Cycloheptene... 

Problem 6.5 Write structural formulas for (a) (/ )-2-mcthyl-3-hexenc (trans), (b) (S)-3-chloro-1 -pentene, (c) (W),(Z)-2-chlor<)-3-heptene (ri.y). 

Analog reagiert 2-Chlor-l-diethylamino-l.l,2-trifluor-ethan zu 2-(Chlor-fluor-mcthyl)-1,3-benzothiazolen 66 ... 

Morpholinium-Salz 6 2-(2-Benzyliden-hydrazino)-4-(5-chlor-3-mcthyl-2-oxo-2,3-dihydro-l, 3-benzoxazol-6-yl)-5-methyl- 75... 

Chlor-benzoyl)-2-pyrrolidino- 136 5-(4-Chlor-bcnzylidenamino)-2-(4-chlor-phenyl)-4-mercapto- -Piperidinium-Salz aus Dithiooxalsaure-diamid/4-Chlor-benzaldehyd/Piperidin 6 5-[4-(4-Chlor-bcnzyloxy)-phenyl]-2,4-dihydro xy-aus Chlor-[4-(4-chlor-benzyloxy)-phenyl]-acetonitril/Thioharnstoff 102 Chlorcarbonyl- 318 2-Chlor-5-chlormcthyl- 128 2-Chlor-4-(6-chlor-2-mcthyl-4H-chromon-... 

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