Chitosan as Transdermal Permeation Enhancer

The chitosan has appeared to be able to interact with negative charges of lipids in the skin [Taveira et al, 2009]. In a study by Wen He et al. [2009], chitosan and its derivatives are found to 

2 Chitosan-Based Transdermal Drug Delivery Systems 

For the purpose of transdermal delivery, chitosan has been largely processed into hydrogel, membrane, microparticle, nanoparticle, and nanocapsule. In addition, it is also used in the processing of liposome and polymersome. 

Nanoparticles are defined as particles with physical dimensions between 1 nm and 1000 nm (Lovestam et al., 2010]. They have been used to restrict the access of drug at the target sites and to deliver the drug at a controlled rate at the site of action (Sagar et al., 2011]. Khalil et al. formulate warfarin-p-cyclodextrln loaded chitosan nanoparticles for transdermal delivery. Chitosan is a hydrophilic 

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