Chitin-chitosan inhibitory effects

It is well known that dietary fat is not absorbed from the intestine unless it has been subjected to the action of pancreatic lipase [1], Previously, we found that basic proteins such as protamines, histones and purothionine inhibited the hydrolysis of triolein emulsified with phosphatidylcholine [2], The inhibition of hydrolysis of dietary fat may cause a decrease or delay in the intestinal absorption of fat and reduce blood chylomicron levels, an excess of which is known to induce obesity [3], Therefore, there was a possibility that inhibitory substances toward pancreatic lipase activity may prevent the onset of obesity induced by feeding a high fat diet to mice. Recently, we found that natural products such as tea saponin, platycodi radix saponin, chitin-chitosan and chondroitin sulfate inhibited the pancreatic lipase activity. In the following section, the anti-obesity effects of these natural products will be described in detail. 

These results suggest that the inhibitory effects of chitin-chitosan on pancreatic lipase activity may be mediated by the interaction between substrate and enzyme through lecithin. Moreover, as shown in Table 4,... 

FIGURE 15.1 Inhibitory effect of chitosan-starch solution against (a) E. coli, (b) S. aureus, and (c) B. subtilis. (From Tripathi, S. et ah, Asian Chitin J., 4, 29, 2008a. With permission.)... 

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