Chiral separation mechanisms binding sites

Chapter 7 is devoted to important physicochemical —basically mechanistic — aspects of the direct enantioseparations, carried out by using either CSP or mobile phase. In such cases, the diversity of the involved separation mechanisms is much greater than the most of other chromatographic modes (and, particularly, when compared with the relatively simple physicochemical rules governing adsorption or partition liquid chromatography). Thus, the author of this chapter discusses enantioseparation in terms of the solute-chiral selector complexation constants, stoichiometry and selectivity of complexation, the nature of the binding sites on the stationary phase surface, and, finally, the supramolecular mechanisms of complexation. 

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