Chiral resolution structures generated

Chirality at surfaces can be manifested in a number of forms including the intrinsic chirality of the surface structure and even the induction of chirality via the adsorption of achiral molecules onto achiral surfaces. The ability of STM to probe surfaces on a local scale with atomic/molecular resolution has revolutionized the understanding of these phenomena. Surfaces that are globally chiral either due to their intrinsic structure or due to the adsorption of chiral molecules have been shown by STM to establish control over the adsorption behavior of prochiral species. This could have profound consequences for the understanding of the origin of homochirality in life on Earth and in the development of new generations of heterogeneous chiral catalysts that may, finally, make a substantial impact on the pharmaceutical industry. 

The second approach is more tedious and more expensive, but may provide a reagent with ideal structural features. To date the approach has been used only for generation of chiral r/ a/ij-2,5-dimethylboro-lane (Figure 10), the synthesis of which involves initial production of the ring system as a mixture of cis and trans isomers, separation and resolution of the pure trans compound, and then manipulation of the boron-bound group to obtain the free borane. ... 

Chiral n complexes of heterocycles with transition metals can serve as effective catalysts for an array of useful organic reactions.The most efficient nucleophilic catalysts previously used had planar structures, e.g., 4-(dimethylamino)pyridine, and therefore required an asymmetric environment in the vicinity of an sp -hybridized nucleophilic atom. In a recent paper, G. C. Fu et al describe a procedure, which they call a second-generation system for kinetic resolution, that employs an iron complex at a mole fraction of 2% as the chiral catalyst, and acetic anhydride as the acylating agent (Figure 9.7.1). The authors attached the 4-(dimethylamino)pyridine moiety to a chiral ferrocene analog. The lower portion of the ferrocene, coordinated to the iron atom is pentaphenylcyclopentadiene, as shown in Figure 9.7.1. 

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