Chiral Recognition Using Modified Cyclodextrins

Chirality of derivatized cyclodextrin was used for recognition of stereoisomers. Phenylazobenzoyl modified y-cyclodextrin was anchored onto silica gel used as stationary phase in HPLC and photoresponsive chromatographic behavior of dansyl amino acid enantiomers was studied [64],... 

Reetz et al. prepared /3-cyclodextrin-modified diphosphine 18 and a series of derivatives by phosphinomethylation of the corresponding amino-substituted cyclodextrin precursors [25], The ligands were used in biphasic hydroformylation of 1-octene and competitive hydrogenation of 1-alkenes, with rather poor results. The chiral cavity in the backbone might achieve molecular recognition of certain pro-chiral substrates and thus provide enantioselectivity in the products. 

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