Chiral metal-organic materials

Chiral Metal-Organic Porous Materials Synthetic Strategies and Applications in Chiral Separation and Catalysis... 

CMOPM Chiral metal-organic porons material... 

Subsequently, several research groups including Lin, Rosseinsky, Xiong, Fedin and others have designed and synthesized several homochiral porous metal-organic materials capable of enantioselective sorption of chiral organic molecules, which are listed in Table 1. 

Certainly, a couple of important points can be made from the entire collection of work on chiral separation by CMOPMs (a) the size of the pore should fit the substrate for proper enantiodifferenciating interactions (b) different mode of interactions of similar kind of substrates with the surface of the pores/channels alters enantioselec-tion ability. So far, the chiral separation ability of chiral metal-organic assanblies has been studied mostly with small molecules. However, the main goal of designing these materials is to utilize them for the separation of the enantiomers of relafively large molecules (e.g., drugs) and fiirther studies are required in this direction. 

The continuous availability of trillions of independent microreactors greatly multiplied the initial mixture of extraterrestrial organics and hydrothermal vent-produced chemicals into a rich variety of adsorbed and transformed materials, including lipids, amphiphiles, chiral metal complexes, amino add polymers, and nudeo-tide bases. Production and chiral amplification of polypeptides and other polymeric molecules would be induced by exposure of absorbed amino adds and organics to dehydration/rehydration cydes promoted by heat-flows beneath a sea-level hydro-thermal field or by sporadic subaerial exposure of near-shore vents and surfaces. In this environment the e.e. of chiral amino adds could have provided the ligands required for any metal centers capable of catalyzing enantiomeric dominance. The auto-amplification of a small e.e. of i-amino adds, whether extraterrestrially delivered or fluctuationally induced, thus becomes conceptually reasonable. 

Towards the end of the second millennium, studies of the transition elements continued to make major contributions to chemical science and technology. The development of new catalysts and reagents represents one area of activity. Examples are provided by the activation of saturated hydrocarbons by rhodium or lutetium complexes, new syntheses of optically active products in reactions which employ chiral metal compounds, and transition metal compounds which catalyse the stereospecific polymerization of alkenes. The ability of transition metal centres to bind to several organic molecules has been exploited in the construction of new two- and three-dimensional molecular architectures (Figure 1.4). New materials containing transition elements are being developed, one... 

---