Chiral Metal Ion-Induced Polyene Cyclizations

Bromine-containing polycyclic terpenoids are also considered to be biosynthesized via the site- and enantioselec-tive bromination of a carbon-carbon double bond followed 

In 2013, Gagne s group demonstrated catalytic enantioselective polyene cyclization and C3-fluorination for 

SCHEME 9.19 Enantioselective polyene cyclizations promoted by dicationic Pt(II) complexes. 

Gagnd s group also has developed chiral platinum-pybox complex 22 that is capable of the cycUzation/protonation of 

SCHEME 9.21 Chiral Pt(ll)-induced enantioselective polyene cyclizations. 

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