Chiral intermediates for drugs

Patel, R. N. 2006b. Biocatalysis Synthesis of chiral intermediates for drugs. Curr. Op. Drug Discov. Dev., 9(10), 741-764. 

Patel RN. Enzymatic synthesis of chiral intermediates for drug development. Adv. Synth. Catal. 2001 343 527-546. 

We sought to examine the enzymatic dioxygenation of aryl silanes using a number of different aromatic dioxygenases in order to determine if such transformations were possible and to define the substrate-specificity profile. We were also motivated by the rich chemistry of silicon-based materials, which includes the hydrosilylation of alkenes and ketones, the addition of electrophiles to vinyl and allyl silanes, and palladium catalyzed cross-coupling of vinyl silanes with aryl halides (13). As a result, silyl functional cw-diols have potential as chiral intermediates for drug development, as polymer precursors/modifiers and as elements in non-linear optical materials. 

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