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Chiral compounds determination

As described earlier, the ACs of many chiral compounds determined by the H NMR anisotropy method were confirmed by X-ray crystallography, which made the H NMR anisotropy method using MaNP acid more reliable. Therefore, even if single crystals for X-ray analysis are not available, ACs can be determined by the H NMR anisotropy method using MaNP acid as exemplified below. [Pg.1653]

The presence of asymmetric C atoms in a molecule may, of course, be indicated by diastereotopic shifts and absolute configurations may, as already shown, be determined empirically by comparison of diastereotopic shifts However, enantiomers are not differentiated in the NMR spectrum. The spectrum gives no indication as to whether a chiral compound exists in a racemic form or as a pure enantiomer. [Pg.56]

A large amount of fuel and environmentally based analysis is focused on the determination of aliphatic and aromatic content. These types of species are often notoriously difficult to deconvolute by mass spectrometric means, and resolution at the isomeric level is almost only possible by using chromatographic methods. Similarly, the areas of organohalogen and flavours/fragrance analysis are dominated by a need to often quantify chiral compounds, which in the same way as aliphatic... [Pg.57]

Eto, S., Noda, H., Noda, A. (1994). Simultaneous determination of antiepileptic dmgs and their metabolites, including chiral compounds, via 3-cyclodextrin inclusion complexes by a switching chromatographic technique. J. Chromatogr. B 658, 385-390. [Pg.340]

From a variety of differently substituted compounds, best results were obtained with the catalysts 195a-c in combination with /-methyl diazoacetate and monoolefins, cyclopropanes were obtained with a relatively high trans/cis ratio and enantiomeric excesses of 44-89% (Table 12). The absolute configuration at the catalyst s chiral center determines the enantioselectivity for both diastereoisomers. [Pg.161]

For a mixture of enantiomers it is thus possible to determine the ee-value without recourse to complicated calibration. The fact that the method is theoretically valid only if the g factor is independent of concentration and if it is linear with respect to ee has been emphasized repeatedly.84-89 However, it needs to be pointed out that these conditions may not hold if the chiral compounds form dimers or aggregates, because such enantiomeric or diastereomeric species would give rise to their own particular CD effects.88 Although such cases have yet to be reported, it is mandatory that this possibility be checked in each new system under study. [Pg.528]

As mentioned in the introduction, the first empirical correlation between the absolute configuration of dopants and the handedness of induced cholesterics was proposed in 1975.20 The first attempt to find a general correlation was a few years later Krabbe et al.58 related the sense of the cholesteric to a stereochemical descriptor of the dopant based on the effective volume of the substituents and listed many compounds following this rule. However, exceptions were described at that time,59 and, furthermore, this approach neglects the role of the structure of the nematic solvent in determining the sense of the cholesteric. It is well known that chiral compounds may induce cholesterics of opposite handedness in different nematics.60,61... [Pg.442]

Liquid Chromatography. The development of rapid, simple liquid chromatographic methods for determining the enantiomeric purity of chiral compounds is probably one of the most important developments in the study of asymmetric synthesis in the last 10 years. Several books have been published providing thorough evaluations of various enantiomeric separation techniques and their practical applications.46... [Pg.28]

As in the case of other chiral compounds, the optical and enantiomeric purity of chiral organosulfur compounds can be determined by various methods (241). The simplest and most common method for the determination of optical purity of a mixture of enantiomers is based on polarimetric measurements. However, this method requires a knowledge of the specific rotation of the pure enantiomer. In the... [Pg.402]

Linear dichroism data with DNA oriented by an electric field [53, 54] or a linear flow [55, 56], under linearly polarised light, lead to determinations of the angle between the absorbing transition dipole moment of the chromophore in the molecule and the DNA helix axis conclusions concerning intercalation may thus be drawn from this technique. Finally, with chiral compounds, circular dichroism is also an attractive method to determine the enantioselectivity in the binding of the molecule [48, 57,58]. [Pg.41]

Lelievre and Gareil (31) studied chiral separations of nonsteroidal anti-inflammatory drugs (carprofen, flurbiprofen, indoprofen, ketoprofen, naproxen, propafenone, and suprofen) and determined the acidity and inclusion complex formation constants of these chiral compounds with different neutral CDs (/3-CD, HP-/3-CD, DM-/3-CD, TM-/3-CD, and HP-y-CD). In... [Pg.200]

The progress toward enantiomerically pnre drngs makes the selective and rapid analysis of enantiomers an important issue, both for chiral parity determinations and for enantioselective bioanalysis. Chankvetadze et al. [198] performed enantioseparations within an analysis time of 1 min for each of two chiral compounds (1,2,2,2-tetraphenylethanol and 2,2 -dihydroxy-6,6 -dimethylbiphenyl) by nsing a homemade capillary column containing monolithic silica modified with amylose tris(3,5-dimethylphenylcarbamate) (Figure 17.10). [Pg.527]

The unambiguous determination of enantiomeric purity1-8 and absolute configuration (see Section A.4.) is an important analytical task in the synthesis, characterization and use of nonracemic chiral compounds. Due to the continued interest in this field, new procedures and improvements to the existing methods are frequently appearing in the literature. Recent papers relevant to this section are found in references 205 207, while references 208-220 contain important review and research articles. [Pg.147]

Chromatography the enantiomers are converted into a pair of diastereomers by chemical reaction with an auxiliary (enantiomerically pure, chiral compound) and the ratio of the peak areas is determined by chromatography on an achiral stationary phase. [Pg.149]

Introduction of the allene structure into cycloalkanes such as in 1,2-cyclononadiene (727) provides another approach to chiral cycloalkenes of sufficient enantiomeric stability. Although 127 has to be classified as an axial chiral compound like other C2-allenes it is included in this survey because of its obvious relation to ( )-cyclooctene as also can be seen from chemical correlations vide infra). Racemic 127 was resolved either through diastereomeric platinum complexes 143) or by ring enlargement via the dibromocarbene adduct 128 of optically active (J3)-cyclooctene (see 4.2) with methyllithium 143) — a method already used for the preparation of racemic 127. The first method afforded a product of 44 % enantiomeric purity whereas 127 obtained from ( )-cyclooctene had a rotation [a]D of 170-175°. The chirality of 127 was established by correlation with (+)(S)-( )-cyclooctene which in a stereoselective reaction with dibromocarbene afforded (—)-dibromo-trans-bicyclo[6.1 0]nonane 128) 144). Its absolute stereochemistry was determined by the Thyvoet-method as (1R, 87 ) and served as a key intermediate for the correlation with 727 ring expansion induced... [Pg.56]

In this way, it is possible to determine the exact enantiomeric ratios of chiral compounds in complex natural materials such as food flavours or essential oils. Even headspace sampling and in vivo headspace sampling from living plants are successfully realised (Fig. 17.9). [Pg.392]


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See also in sourсe #XX -- [ Pg.1534 , Pg.1629 , Pg.1633 , Pg.1634 , Pg.1635 , Pg.1636 , Pg.1637 , Pg.1638 , Pg.1639 , Pg.1640 , Pg.1641 ]




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