Chiral asymmetric bioreduction

Swiderska, M. A., and Stewart, J. D. 2006b. Asymmetric bioreduction of P-nitro acrylates as a route to chiral p2-amino acids. Org. Lett., 8, 6131-6133. [Pg.372]

Figure 13.5 (a) Asymmetric bioreduction to chiral alcohol as key intermediate in ezetimibe synthesis, (b) Microbial reduction of ezetimibe precursor to bioactive form of ezetimibe. [Pg.341]

Inoue, K., Makino, Y., Dairi, T. and Itoh, N. (2006) Gene cloning and expression of Leifsonia alcohol dehydrogenase (LSADH) involved in asymmetric hydrogen-transfer bioreduction to produce (/ )-form chiral alcohols. Bioscience Biotechnology and Biochemistry, 70 (2), 418-426. [Pg.165]

Itoh, N., Nakamura, M., Inoue, K. and Makino, Y. (2007) Continuous production of chiral 1,3-butanediol using immobilized biocatalysts in a packed bed reactor promising biocatalysis method with an asymmetric hydrogen-transfer bioreduction. Applied Microbiology and Biotechnology, 75 (6), 1249-1256. [Pg.165]

A bioreduction system might be applied to many NAD(P)H-dependent enzyme reactions other than carbonyl reduction. Recently, two novel old yellow enzymes (OYEs) catalyzing the asymmetric hydrogenation of C=C bonds were found and applied to a bioreduction system for the production of double chiral compounds. [Pg.365]

Application of bioreduction to the asymmetric syntheses of chiral drugs 01MI118. [Pg.25]

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