Chiral amines biocatalytic approaches

The significance of chiral unnatural amino acids to drug and natural product synthesis is shown in the example of the antihypertensive dmg omapatrilat (Vanlev ), which is composed of no less than three amino acid derived intermediates [144-147]. Diverse biocatalytical approaches to L-6-oxonorleucine were made (Fig. 21). Two different enzymes were applied in reductive amination reactions to produce derivatives of the desired intermediate. 

Figure 14.1 Biocatalytic approaches for the synthesis of chiral amines.

Ghislieri, D. and Turner, N. J. (2014). Biocatalytic approaches to the synthesis of enanti-omerically pure chiral amines. Top. Catal., 57,284 -300. 

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