Chimeric peptides cyclic

Chimeric peptides are unnatural constructs consisting of bioactive compounds from at least two different peptide(s) and/or protein(s) or two sequences from different parts of the same protein. Such multifunctional peptide combinations are prepared to enhance the biological activity or selectivity of their components. New biological effects can also be achieved with the chimera. In this chapter the synthesis of three different types of chimeric peptides will be described. In a linear chimera, two peptide epitopes from different parts of glycoprotein D (gD) of herpes simplex virus (HSV) are combined. A branched chimera, built from linear peptides, consists of tuftsin oligomers with immunostimulatory activity and an epitope peptide of HSV gD. The third compound is a cyclic chimeric molecule, where a-cono-toxin GI as a host peptide is modified by the incorporation of a core epitope from HSV gD as a guest sequence. 

The methods described outline the synthesis of (1) linear, (2) branched, and (3) cyclic chimeric peptides. The linear peptide consists of two different epitope... 

Cyclic Hexapeptides and Chimeric Peptides and Mimics of Tendamistat. 

It has also been described that combining a CPP with a cancer-related peptide yields a chimeric peptide with tumor specificity that can carry cargo molecules inside cells (Mae et al., 2008). For instance, Myrberg et al. (2008) successfully attached the breast tumor cyclic nonapeptide named PEGA (Essler and Ruoslahti, 2002) to the well-studied CPP pVEC (Elmquist et al 2001). These authors demonstrated that the peptide alone does not cross the plasma membrane. However, when conjugated with... 

---