Chemotherapy dose density

Piccart MJ, Biganzoh L, Di Leo A. The impact of chemotherapy dose density and dose intensity on breast cancer outcome what have we learned Eur J Cancer 2000 36(Suppl 1) S4-S 10. 

Dose intensity can be increased by shortening the interval between cycles (i.e., dose density). The data with dose-dense chemotherapy regimens is conflicting, with findings of both no survival difference and improved survival with dose-dense regimens. " ... 

I New Chemotherapy Regimens. More recently, new regimens have been developed with increased dose-intensity or dose-density. Two relatively new regimens (BEACOPP and Stanford V) are variations of the above hybrid regimens that administer drugs with a shorter frequency or have escalated the dose of the most active agents. Since the majority of patients in the recent trials also received radiation therapy, results of these promising new trials are discussed in the next section. 

Several smdies have attempted to improve treatment results by increasing chemotherapy dose (i.e., dose-intensity), shortening the interval between chemotherapy cycles (i.e., dose-density), or both. Because of the increased risk of severe neutropenia, these approaches require growth factor support. Although results of these studies have not consistently shown improved survival, encouraging results from several recently published smdies suggest that these approaches be evaluated in future randomized trials. ... 

Increased dose density is achieved by reducing the interval between each dose of chemotherapy. The cumulative drug dose remains constant, but the same amount of drug is administered over a shorter period. Mathematical models of tumour growth have provided the basis... 

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