Chemotherapeutic agents delivery using

There have been few reports on the cUnical use of albumin microspheres for the delivery of drugs. The limited clinical trials, using chemotherapeutic agents, employ a technique referred to as arterial chemoembolism in which the drug-containing microspheres... 

Intraperitoneal administration of chemotherapeutic agents has been used for many years as a way of increasing the delivery of drugs to tumors (e.g., ovarian carcinoma) located in the peritoneal cavity (Markman, 1986 Howell and Zimra, 1988). Cisplatin (Casper et al., 1983 Markman et al., 1985), cytosine arabinoside (Ara-C) (King et al., 1984 Markman et al., 1985, 1986), and bleomycin (Markman et al., 1986) are examples of intraperitoneally administered drugs which were already successfully applied in clinical settings. 

Osmotic disruption of the BBB has been used to increase the delivery of chemotherapeutic agents to the brain in the treatment of CNS tumors in rats.13 15 The clinical benefits of increased delivery of chemotherapeutic agents to the brain through osmotic disruption of the BBB have been demonstrated by the increased survival rates observed in patients with primary CNS lymphoma46 47 and malignant gliomas.47,48... 

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