Chemoenzymatic Multistep One-Pot Processes

However, in spite of aU these advantages, there are also some challenges ahead when developing chemoenzymatic one-pot processes. A major challenge is to achieve compatibility between the different types of classic chemical and chemocatalytic processes on one hand (which are often preferentially carried out in organic media) and enzyme catalysis (for which water is typically the reaction medium of choice) on the other. Furthermore, high conversions and yields of the individual steps are crucial as well in order to reduce the complexity of the finally resulting reaction mixture. 

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