Chemo-and regioselective oxidation

Although not directly relevant to this review, it should be noted that Sanford, Shi and Buchwald have also reported a palladium-catalyzed reaction for the chemo-and regioselective oxidative cross-coupling between ligand coordinated L-Cat-H substrates and simple arenes (Ar-H) [55-57]. 

The strategy required the chemo- and regioselective oxidation at C9a, a transformation related to the recent efforts to perform regioselective C-H oxidation of complex molecules or natural products (Scheme 24). ° From a general perspective, allylic oxidation seemed feasible and literature precedents were actually encouraging since the oxidation at C9a of R)-22 was reported by Hertweck with cytochrome P450 monooxygenase AurH on an analytical scale. 

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