Chemically modified glycopeptides

All these chemically modified glycopeptides have been helpful in understanding the mechanism of the chiral recognition process mediated by these macrocycles. 

Carboxylic acid-terminated organosilanes were used in the early studies on chemically bonded glycopeptides to immobilize vancomycin and thiostrepton via then-amino groups, leading to the formation of stable amide bonds between antibiotics and modified silica [7]. In a typical reaction, 4 g of dry silica gel is slurried on 50 mL of dry toluene. Two grams of [l-(carbomethoxy)ethyl]methyldichlorosilane or [2-(carbomethoxy)ethyl]trichlorosilane is dissolved in 15 mL of dry toluene contained in a dropping flask. The organosilane solution is added dropwise over 30 min... 

GlycoX includes an oligosaccharide calculator for assigning oligosaccharide compositions for N-linked, 0-linked, and chemically modified oligosaccharides. An isotope filter is also included to determine the monoisotopic quasimolecular ions in mixtures of glycopeptides or glycans readily. 

Miscellaneous Polysaccharides, Oligosaccharides, and Glycopeptides. — Lamin-aribiose has been modified to form the 3-methyl and (3-benzyI glycosides,and 4-0-o -D-mannopyranosyl-D-mannose has been chemically modified also. ... 

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