Chemical structure diagnostic testing

This plant yielded (— )-lobeline and a new base, eampedine (C14H17O2N), whose structure (26) is based on physical methods and diagnostic chemical tests for the methylenedioxy group (35). 

As the collection of recent reviews in the topic shows [12-20], a rather large consensus appears in the computation or experimental tests for the diagnosis of the aromaticity/antiaromaticity (energetic, structural, magnetic, chemical reactivity, and electronic diagnostic tools), whereas the mechanisms themselves still remain open to the debate. The primary controversy in the area involves the questions of whether aromaticity/antiaromaticity can be quantified and, if so, which of the methods commonly used to evaluate aromaticity/antiaromaticity is most appropriate. The literature on aromaticity and its measure is so vast that I must be content here with outlining briefly only the aromaticity indicators which have been extensively used to diagnose aromaticity/antiaromaticity in the domain of all-metal aromatics. 

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