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Chemical stability of drugs

Ahlneck C, Zografi G. The molecular basis of moisture effects on the physical and chemical stability of drugs in the solid state. Int J Pharm 1990 62 87-95. [Pg.108]

Water can have a significant impact on the physical and chemical stability of drugs. Water may be present as part of the crystalline lattice (hydrate), or it may be on the surface ( free ) or more tightly incorporated ( bound ). The evaluation of the type of water present in a pharmaceutical material has been determined using subambient DSC (thermoporosimetry), such as... [Pg.401]

Loftsson, T. Effects of cyclodextrins on the chemical stability of drugs in aqueous solutions. Drug Stab. 1995,1 (1), 22-33. [Pg.693]

The influence of solvent polarity on the chemical stability of drugs depends on the nature of the reactants, products, and transition state of the reactants. This was discussed by Connors, Amidon, and Kennon. for various combinations of reactants. In general, if a vehicle is less repulsive to the transition state than... [Pg.816]

See other pages where Chemical stability of drugs is mentioned: [Pg.167]    [Pg.219]    [Pg.297]    [Pg.306]    [Pg.816]    [Pg.3300]    [Pg.427]    [Pg.2]    [Pg.3]    [Pg.4]    [Pg.6]    [Pg.8]    [Pg.10]    [Pg.12]    [Pg.14]    [Pg.16]    [Pg.18]    [Pg.20]    [Pg.22]    [Pg.24]    [Pg.26]    [Pg.28]    [Pg.30]    [Pg.32]    [Pg.34]    [Pg.34]    [Pg.36]    [Pg.38]    [Pg.40]    [Pg.42]    [Pg.44]    [Pg.46]    [Pg.48]    [Pg.50]    [Pg.52]    [Pg.54]   


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