Chemical shift imaging technique

Fl.T. Tran, Q. Guo, D.J. Schumacher, R.B. Buxton, R.F. Mattrey, F chemical shift Imaging technique to measure Intracellular p02 in vivo using perflubron, Acad. Radiol. 2 (1995) 756-761. 

Where multivoxel localization is advantageous, chemical shift imaging techniques can be applied in one, two or three dimensions, but relatively poor spatial resolution is obtainable and long acquisition times are usually required. 

The current MRI techniques provide information not only on the internal structure of various foodstuffs but also on the distribution of various compounds (chemical shift imaging), mobility and diffusion of various compounds (like water, oil, or compounds from various packing materials), or dynamic changes like crystallization. 

The third alternative is a more robust, sensitive and specialized fonn of the first, in that only hydrogen nuclei indirectly spin-spin coupled to in a specific molecular configuration are imaged. In achieving selectivity, the technique exploits the much wider chemical shift dispersion of compared to H. The metliod involves cyclic transfer from selected H nuclei to indirectly spin-spin coupled C nuclei and back according to the sequence... 

Magnetic resonance imaging is a noninvasive structural technique for complex systems of molecules, such as people. In its simplest form, MRI portrays the concentration of protons in a sample. If the sample—which may be a living human body—is exposed to a uniform magnetic field in an NMR spectrometer and if we work at a resolution that does not show any chemical shifts or fine structure, then the protons... 

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