Chemical properties of cyclopropane

The physical and chemical properties of cyclopropane are similar to those of olefins, because of the increase in the p-orbital nature of the C-C bonds [50,51]. In bicycIo[4.1.0]heptan-2-one, the cyclopropyl ring is constrained essentially in an axial-like orientation to the plane of the cyclohexanone ring [52,53], Therefore, replacing the 2 -double bond of ABA with cyclopropane would introduce 1,3-diaxial steric repulsion between the cyclopropyl ring and the 6 -methyl group in one conformer, to pull conformational equilibrium towards the other [Fig. (4)]. On the other hand, replacing the C-5 -C-6 single bond with cyclopropane can... 

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