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Chemical permeation enhancements

Whitehead K, Mitragotri S (2008) Mechanistic analysis of chemical permeation enhancers for oral drug delivery. Pharm Res 25 1412-1419... [Pg.100]

TABLE 5 Desired Properties of Chemical Permeation Enhancers... [Pg.803]

The systematic study of polar permeant permeation served to confirm the existence of a porous permeation pathway through the HEM. It also led to the characterization of important properties of this pathway. The results of this study demonstrated that the diffusion of polar permeants through skin is limited by the low effective porosity of the HEM and by hindrance effects due to restrictive pore dimensions. Effectively enhancing the transport of polar drugs in the MW range of many therapeutic peptides may require increasing the effective Rp of the HEM as well as the effective porosity/tortuosity ratio. Perhaps novel combinations of chemical permeation enhancers and physical means such as an applied electrical field or ultrasound may be necessary to achieve this objective. [Pg.285]

Transdermal Electrophoretic (iontophoresis), electroporation, chemical permeation enhancers, prodrugs, ultrasonics ... [Pg.454]

Murthy, S.N. and Hiremath, R.R. (2001) Physical and chemical permeation enhancers in transdermal delivery of terbutaline sulphate . AAPS PharmSciTech. 2, 1-5. [Pg.137]

See other pages where Chemical permeation enhancements is mentioned: [Pg.203]    [Pg.233]    [Pg.235]    [Pg.237]    [Pg.239]    [Pg.241]    [Pg.243]    [Pg.245]    [Pg.247]    [Pg.249]    [Pg.251]    [Pg.253]    [Pg.642]    [Pg.650]    [Pg.803]    [Pg.270]    [Pg.3846]    [Pg.3846]    [Pg.3851]    [Pg.451]    [Pg.451]    [Pg.464]    [Pg.465]   
See also in sourсe #XX -- [ Pg.233 , Pg.234 , Pg.235 , Pg.236 , Pg.237 , Pg.238 , Pg.239 , Pg.240 , Pg.241 , Pg.242 , Pg.243 , Pg.244 , Pg.245 , Pg.246 , Pg.247 , Pg.248 , Pg.249 ]



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