Combination chemical genetics

This work elegantly demonstrates power of combined ABPP and chemical genetics approaches in understanding microbial pathogenesis, and has made a very real contribution to the identification of potential novel dmg targets. 

Lehdr J., et al. (2008) Combination chemical genetics. Nature Chemical Biology. DOI 10.1038/ nchembio.120... 

Fig. 4.1-1 Chemical Complementation combines the power of genetic assays and small molecule chemistry to understand small molecule function and develop new chemistry inside the cell.

A chemical genetic approach (Figure 1C) combines the use of an organized chemical library with phenotype screens and a robust target identification method to produce novel targets of interest coupled with interacting chemistry. 

The blastocyst (early embryo) is relatively resistant to damage in the first 7 days, for up to 75% of cells can be destroyed before tissue differentiation and the embryo can still survive. What might happen if garden pesticides, or house builders formaldehyde containing glue and chemicals, are combined into the genetic material If it is ever confirmed, then we may have the inkling of what makes up the 65% of the unknown causes of developmental defects mentioned by Wilson... 

Synthetic lethal chemical screening Synthetic lethal chemical screening is basically a combination of classical and chemical genetics and it is particularly suitable for the identification of potential antitumor agents. 

Combination drugs and multicomponent therapeutics (e.g., herbs and natural products) have been used since ancient times. There is widespread evidence that combinations of compounds can be more effective than the sum of the effectiveness of the individual agents themselves, a result that can be rationalized using principles derived from modern systems and molecular biology. Combination chemical genetics coupled with the informatics methods of system biology could provide deeper insights into the... 

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